N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-4AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.1 and 0.625 µM

N-(4-acetamidophenyl)-Indomethacin amide – 1 mg

Brand:
Cayman
CAS:
261766-23-8
Storage:
-20
UN-No:
Non-Hazardous - /

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 µM, respectively.{8243,8513} It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.  

 

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SKU: 70278 - 1 mg Category:

Description

N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-4AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.1 and 0.625 µM, respectively.{8243,8513} It is about 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Formal name: N-(4-acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

Synonyms:  N-4AIA

Molecular weight: 490

CAS: 261766-23-8

Purity: ≥98%

Formulation: A crystalline solid

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