N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 52 nM. It is about 1

N-(3-pyridyl)-Indomethacin amide – 10 mg

Brand:
Cayman
CAS:
261766-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 µM. It is about 1,300 times less potent as an inhibitor of ovine recombinant COX-1.{8243} However, N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.{8513}  

 

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Description

N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 52 nM. It is about 1,300 times less potent as an inhibitor of ovine COX-1.{8243} However, N-3PyIA does not distinguish between ovine COX-1 and -2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.{8513}

Formal name: N-(3-pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

Synonyms:  N-3PyIA

Molecular weight: 433.9

CAS: 261766-29-4

Purity: ≥98%

Formulation: A crystalline solid

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