A bacterial quorum sensing compound that possesses antimicrobial activity

N-3-oxo-tetradec-7(Z)-enoyl-L-Homoserine lactone – 5 mg

Brand:
Cayman
CAS:
482598-46-9
Storage:
-20
UN-No:
De Minimis - 1648 / 3

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} 3-oxo-C14:1-Δ7cis-(L)-HSL is a bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity.{17157,16341} This compound is structurally related to other 3-oxo-monounsaturated (N-acylated homoserine lactones) AHLs such as 3-oxo-C16:1-Δ11cis-(L)-HSL (Catalog No. 10011238).  

 

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Description

A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity

Formal name: 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-7-tetradecenamide

Synonyms:  3-oxo-C14:1-Δ7cis-(L)-HSL

Molecular weight: 323.4

CAS: 482598-46-9

Purity: ≥98%

Formulation: A solution in acetonitrile

Product Type|Biochemicals|Homoserine Lactones||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing

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