An AHL autoinducer that promotes the expression of the transcriptional activator (and LuxR homolog) TraR

N-3-oxo-octanoyl-L-Homoserine lactone – 50 mg

Brand:
Cayman
CAS:
147795-39-9
Storage:
-20
UN-No:
Non-Hazardous - /

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} In the gram-negative bacterium A. tumefaciens, N-3-oxo-octanoyl-L-homoserine lactone promotes the expression of the transcriptional activator (and LuxR homolog) TraR.{16347}  

 

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Description

An AHL autoinducer that promotes the expression of the transcriptional activator (and LuxR homolog) TraR

Formal name: 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-octanamide

Synonyms:  3-oxo-C8-HSL|N-β-oxo-octanoyl-L-Homoserine lactone

Molecular weight: 241.3

CAS: 147795-39-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Homoserine Lactones||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing

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