N-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM

N-(2-phenylethyl)-Indomethacin amide – 5 mg

Brand:
Cayman
CAS:
261766-32-9
Storage:
-20
UN-No:
Non-Hazardous - /

N-(2-phenylethyl)-indomethacin amide (N-2PIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively.{8243,8513} It is over 400 times less potent as an inhibitor of human recombinant and ovine COX-1. N-2PIA shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.{8243}  

 

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Description

N-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively.{8243,8513} It is over 400 times less potent as an inhibitor of ovine COX-1.{8513}

Formal name: N-(2-phenylethyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

Synonyms:  N-2PIA

Molecular weight: 461

CAS: 261766-32-9

Purity: ≥98%

Formulation: A crystalline solid

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