An inhibitor of HIF-1 signaling (IC50 = 0.32 μM in a cell-based HRE reporter assay under hypoxic conditions); inhibits hypoxia-induced increases in HIF-1α levels in MDA-MB-231

N-(2-Fluorophenethyl)-5-(2-methoxyphenyl)picolinamide – 10 mg

Brand:
Cayman
CAS:
2380261-53-8
Storage:
-20
UN-No:
Non-Hazardous - /

N-(2-Fluorophenethyl)-5-(2-methoxyphenyl)picolinamide is an inhibitor of hypoxia-inducible factor (HIF-1) signaling (IC50 = 0.32 μM in a cell-based hypoxia responsive element (HRE) reporter assay under hypoxic conditions).{50774} It inhibits hypoxia-induced increases in HIF-1α levels in MDA-MB-231, SKOV3, and HeLa cells in a concentration-dependent manner. N-(2-Fluorophenethyl)-5-(2-methoxyphenyl)picolinamide also inhibits hypoxia-induced VEGF expression and capillary-like tube formation in human umbilical vein endothelial cells (HUVECs) and inhibits migration and invasion of MDA-MB-231 cells in wound healing and transwell assays under hypoxic conditions. It also reduces lung metastasis in an MDA-MB-231 mouse xenograft model when administered at doses of 15 and 30 mg/kg every other day.  

 

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SKU: 29740 - 10 mg Category:

Description

An inhibitor of HIF-1 signaling (IC50 = 0.32 μM in a cell-based HRE reporter assay under hypoxic conditions); inhibits hypoxia-induced increases in HIF-1α levels in MDA-MB-231, SKOV3, and HeLa cells in a concentration-dependent manner; inhibits hypoxia-induced VEGF expression and capillary-like tube formation in HUVECs; inhibits migration and invasion of MDA-MB-231 cells in wound healing and transwell assays under hypoxic conditions; reduces lung metastasis in an MDA-MB-231 mouse xenograft model at 15 and 30 mg/kg every other day

Formal name: N-[2-(2-fluorophenyl)ethyl]-5-(2-methoxyphenyl)-2-pyridinecarboxamide

Synonyms: 

Molecular weight: 350.4

CAS: 2380261-53-8

Purity: ≥98%

Formulation: A crystalline solid

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