A microbial metabolite; active against Gram-positive bacteria but not Gram-negative bacteria or fungi in an agar diffusion assay at 80 µg/disc; inhibits 5-LO activity (IC50 = 1.9 µM for the recombinant human enzyme); cytotoxic to 26-L5 colon cancer cells at 3 µg/ml

Myxochelin A – 1 mg

Brand:
Cayman
CAS:
120243-02-9
Storage:
-20
UN-No:
Non-Hazardous - /

Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities.{53609} It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 µg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 µM for the recombinant human enzyme.{53610} It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 µg/ml.{53611}  

 

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Description

A microbial metabolite; active against Gram-positive bacteria but not Gram-negative bacteria or fungi in an agar diffusion assay at 80 µg/disc; inhibits 5-LO activity (IC50 = 1.9 µM for the recombinant human enzyme); cytotoxic to 26-L5 colon cancer cells at 3 µg/ml

Formal name: N,N′-[(1S)-1-(hydroxymethyl)-1,5-pentanediyl]bis[2,3-dihydroxy-benzamide

Synonyms:  (S)-Myxochelin A

Molecular weight: 404.4

CAS: 120243-02-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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