A trichothecene mycotoxin; inhibits proliferation of A549

Myrothecine A – 1 mg

Brand:
Cayman
CAS:
910292-40-9
Storage:
-20
UN-No:
Non-Hazardous - /

Myrothecine A is a trichothecene mycotoxin that has been found in M. roridum and has anticancer activities.{48753,48754} It inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (IC50s = 95, 70, 60, and 25 µM, respectively).{48753} Myrothecine A (50 µM) induces G1 cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells.{48753,48754}  

 

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SKU: 28193 - 1 mg Category:

Description

A trichothecene mycotoxin; inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (IC50s = 95, 70, 60, and 25 µM, respectively); induces G1 cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells at 50 µM

Formal name: (2R,4R,7Z,11S,15E,19aR,22S,23S,23aR,25R,26S,27R)-11-acetyl-3,4,10,11,21,22,23,23a-octahydro-22,25,27-trihydroxy-22,26-dimethyl-20H-11,15-methano-23,2,4,19a-[1,2]propanediyl[3]ylidene-2H,13H,19H-1,5,12,18-benzotetraoxacycloheneicosin-6,17(9H,14H)-dione

Synonyms: 

Molecular weight: 546.6

CAS: 910292-40-9

Purity: ≥70%

Formulation: A solid

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