Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi

Myriocin – 10 mg

Brand:
Cayman
CAS:
35891-70-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A.{8482} Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. {14764} It disrupts substratum adhesion of melanoma cells.{14763} It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis.{14764,2816} Myriocin suppresses replication of the hepatitis C virus in a murine model.{14762}  

 

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SKU: 63150 - 10 mg Category:

Description

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A.{8482} Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. {14764} It disrupts substratum adhesion of melanoma cells.{14763} It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis.{14764,2816} Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.{14762}

Formal name: 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid

Synonyms:  ISP-1|Thermozymocidin

Molecular weight: 401.5

CAS: 35891-70-4

Purity: ≥98%

Formulation: A crystalline solid

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