An inhibitor of the MDM2 protein and XIAP mRNA interaction; binds to the RING domain of MDM2 (Kd = 2.34 µM); decreases the levels of MDM2 and XIAP; induces autoubiquitination and degradation of MDM2 and increases the half-life of p53 in EU-1 cells; cytotoxic to a variety of ALL and neuroblastoma cancer cell lines but not to NBMM cells; increases survival in an EU-1 mouse model of leukemia at 100 mg/kg

MX69 – 5 mg

Brand:
Cayman
CAS:
1005264-47-0
Storage:
-20
UN-No:
Non-Hazardous - /

MX69 is an inhibitor of the interaction between the ubiquitin ligase MDM2 protein and XIAP mRNA.{45164} It binds to the RING domain of MDM2 (Kd = 2.34 µM) and decreases the levels of MDM2 and XIAP in a concentration-dependent manner without affecting the levels of Bcl-2, cIAP-1, and cIAP-2. It induces autoubiquitination and degradation of MDM2 and increases the half-life of p53 in EU-1 cells. MX69 is cytotoxic to a variety of acute lymphoblastic leukemia (ALL) and neuroblastoma cancer cell lines but not to human normal bone marrow mononuclear (NBMM) cells. It increases survival in an EU-1 mouse model of leukemia when administered at a dose of 100 mg/kg.  

 

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SKU: 27224 - 5 mg Category:

Description

An inhibitor of the MDM2 protein and XIAP mRNA interaction; binds to the RING domain of MDM2 (Kd = 2.34 µM); decreases the levels of MDM2 and XIAP; induces autoubiquitination and degradation of MDM2 and increases the half-life of p53 in EU-1 cells; cytotoxic to a variety of ALL and neuroblastoma cancer cell lines but not to NBMM cells; increases survival in an EU-1 mouse model of leukemia at 100 mg/kg

Formal name: 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-benzoic acid

Synonyms: 

Molecular weight: 474.6

CAS: 1005264-47-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death

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