A full GABAA agonist and partial GABAC agonist; binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM

Muscimol – 5 mg

Brand:
Cayman
CAS:
2763-96-4
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM.{18163} Benzodiazepines enhance the effects of muscimol via GABAA without altering its binding.{18163,18162} Muscimol activates GABAC receptors with an EC50 value of 1.3 μM.{18156} It also acts as an inhibitor of GABAA uptake and a substrate for the GABA-metabolizing enzyme GABA transaminase.{17741} Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs in vivo.{18159,18160}  

 

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Description

A full GABAA agonist and partial GABAC agonist; binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 of 200 nM; activates GABAC receptors with an EC50 of 1.3 μM; impairs memory formation and retrieval; attenuates airway constriction

Formal name: 5-(aminomethyl)-3(2H)-isoxazolone

Synonyms:  Agarin|Pantherine

Molecular weight: 114.1

CAS: 2763-96-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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