A secondary bile acid produced from α-muricholic acid and β-muricholic acid; metabolite of lithocholic acid; prevents gallstones in hamsters; does not resolve gallstones in prairie dogs and induces formation of insoluble bile acid salt gallstones; rapidly absorbed in humans

Murideoxycholic Acid – 1 mg

Brand:
Cayman
CAS:
668-49-5
Storage:
-20
UN-No:
Non-Hazardous - /

Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid (Item No. 20291) and β-muricholic acid (Item No. 20287).{45190} It is also a metabolite of lithocholic acid (Item No. 20253) in liver S9 fractions from humans and other species.{46202} MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.{37053,37054} Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl taurine.{37054} In humans, MDCA is rapidly absorbed and is metabolized as an endogenous bile acid with a half-life of approximately 3.5 days.{37055}  

 

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Description

A secondary bile acid produced from α-muricholic acid and β-muricholic acid; metabolite of lithocholic acid; prevents gallstones in hamsters; does not resolve gallstones in prairie dogs and induces formation of insoluble bile acid salt gallstones; rapidly absorbed in humans

Formal name: 5β-3α,6β-dihydroxy-cholan-24-oic acid

Synonyms:  MDCA|Murocholic Acid|NSC 18166

Molecular weight: 392.6

CAS: 668-49-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome

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