Mulberroside A – 25 mg

Brand:
Cayman
CAS:
102841-42-9
Storage:
-20
UN-No:
Non-Hazardous - /

Mulberroside A is a phenol and stilbene glucoside form of oxyresveratrol (Item No. 12028) originally isolated from M. alba (mulberry) roots that has diverse biological activities.{48392,48393,48395,48394} It inhibits pregnane X receptor-mediated P-glycoprotein (P-gp) luciferase reporter activity induced by rifampicin (Item No. 14423) in LS174T cells when used at concentrations ranging from 5 to 20 μM.{48392} Mulberroside A decreases expression of TNF-α, IL-1β, and IL-6, inhibits caspase-1 activation, and increases cell viability in an isolated rat cortical neuron model of oxygen-glucose deprivation-induced ischemia and reperfusion injury.{48393} Topical administration of mulberroside A (2 and 5% v/v) reduces UVB-induced hyperpigmentation, levels of the melanogenesis enzymes tyrosinase, tyrosinase-related protein 1 (TRP-1), and microphthalmia-associated transcription factor (MITF), and tyrosinase activity in brown guinea pig skin.{48395} Mulberroside A (10, 20, and 40 mg/kg) decreases serum levels of uric acid, creatinine, and urea nitrogen, reduces renal vacuolar and granular degeneration, and increases fractional excretion of uric acid and urinary urate excretion in hyperuricemic mice.{48394}  

 

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SKU: 27545 - 25 mg Category:

Description

A phenol with diverse biological activities; inhibits rifampicin-induced pregnane X receptor-mediated P-gp luciferase reporter activity in LS174T cells from 5-20 μM; decreases expression of TNF-α, IL-1β, and IL-6, inhibits caspase-1 activation, and increases cell viability in an isolated rat cortical neuron model of oxygen-glucose deprivation-induced ischemia and reperfusion injury; topical administration reduces UVB-induced skin hyperpigmentation, levels of the melanogenesis enzymes tyrosinase, TRP-1, and MITF, and tyrosinase activity in brown guinea pig skin at 2 and 5% v/v; decreases serum levels of uric acid, creatinine, and urea nitrogen, reduces renal vacuolar and granular degeneration, and increases fractional excretion of uric acid and urinary urate excretion in hyperuricemic mice at 10, 20, and 40 mg/kg


Formal name: 3-[(1E)-2-[4-(β-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl, β-D-glucopyranoside

Synonyms: 

Molecular weight: 568.5

CAS: 102841-42-9

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Natural Products|Stilbenes||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection|Ischemia