A selective inhibitor of the HER2

Mubritinib – 50 mg

Brand:
Cayman
CAS:
366017-09-6
Storage:
-20
UN-No:
Non-Hazardous - /

Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.{21787} It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM).{21787} Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.{21787,21788}  

 

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SKU: 12096 - 50 mg Category:

Description

A selective inhibitor of the HER2, inhibiting HER2 phosphorylation with an IC50 value of 6 nM; without effect on EGFR, FGFR, PDGFR, Jak1, Src, and Blk (IC50 > 25 μM); inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo

Formal name: 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole

Synonyms:  TAK-165

Molecular weight: 468.5

CAS: 366017-09-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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