A DNA alkylating agent; active metabolite of dacarbazine (DTIC); active degradation product of temozolomide; cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%

MTIC – 1 mg

Brand:
Cayman
CAS:
3413-72-7
Storage:
-20
UN-No:
Non-Hazardous - /

MTIC is a DNA alkylating agent, an active metabolite of dacarbazine (DTIC; Item No. 21877), and an active degradation product of temozolomide (Item No. 14163).{39894,39895,39896} MTIC is cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, when used at a concentration of 1 mM.{39895} It is also cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner.{39896} In vivo, MTIC induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks.{39897}  

 

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Description

A DNA alkylating agent; active metabolite of dacarbazine (DTIC); active degradation product of temozolomide; cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, at 1 mM; cytotoxic to TLX5 murine lymphoma cells; induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks

Formal name: 5-[2-(methylimino)hydrazinyl]-1H-imidazole-4-carboxamide

Synonyms:  NSC 407347

Molecular weight: 168.2

CAS: 3413-72-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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