A partial antagonist of CXCR4; reduces inflammation in a mouse model of experimental colitis; prevents the production of TNF-α

MSX-122 – 10 mg

Brand:
Cayman
CAS:
897657-95-3
Storage:
-20
UN-No:
Non-Hazardous - /

MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).{38354} It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and IL-6. MSX-122 also reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli. It decreases metastases in mouse models utilizing MDA-MB-231 breast cancer or 686LN-Ms squamous cell carcinoma cells injected intravenously or OMM2.3 melanoma cells inoculated into the eye.  

 

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SKU: 23426 - 10 mg Category:

Description

A partial antagonist of CXCR4; reduces inflammation in a mouse model of experimental colitis; prevents the production of TNF-α, IL-1β, and IL-6; reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli; decreases metastases in three different mouse models

Formal name: N1,N4-di-2-pyrimidinyl-1,4-benzenedimethanamine

Synonyms: 

Molecular weight: 292.3

CAS: 897657-95-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases

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