A telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay); selective for telomerase over DNA polymerase (3 μM); inhibits growth of U937 cells (GI50 = 1.7 μM); reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells; decreases survival of H460 and H1299 NSCLC cells; reduces tumor size by 70% in an H460 mouse xenograft model (40 mg/kg); inhibits replication of HSV-2 and a clinical isolate of HSV-1; decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1

MST-312 – 5 mg

Brand:
Cayman
CAS:
368449-04-1
Storage:
-20
UN-No:
Non-Hazardous - /

MST-312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay).{40972} It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells.{40973} MST-312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population.{40974} In vivo, MST-312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST-312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.{40975}  

 

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SKU: 24301 - 5 mg Category:

Description

A telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay); selective for telomerase over DNA polymerase (3 μM); inhibits growth of U937 cells (GI50 = 1.7 μM); reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells; decreases survival of H460 and H1299 NSCLC cells; reduces tumor size by 70% in an H460 mouse xenograft model (40 mg/kg); inhibits replication of HSV-2 and a clinical isolate of HSV-1; decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1

Formal name: N,N’-1,3-phenylenebis[2,3-dihydroxy-benzamide

Synonyms:  Telomerase Inhibitor IX

Molecular weight: 380.4

CAS: 368449-04-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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