A thiazolidinedione; inactivates MPC (IC50 = 1.2 mM) without affecting PPARγ (IC50 = 31.65 mM) in vitro; enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes; dietary administration lowers blood glucose levels in obese

MSDC-0160 – 5 mg

Brand:
Cayman
CAS:
146062-49-9
Storage:
-20
UN-No:
Non-Hazardous - /

MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities.{9838} It inactivates the mitochondrial pyruvate carrier (MPC; IC50 = 1.2 mM) without affecting peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 31.65 mM) in vitro.{48099} MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.{9838} Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson’s disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR).{48099} It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson’s disease.  

 

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SKU: 71748 - 5 mg Category:

Description

A thiazolidinedione; inactivates MPC (IC50 = 1.2 mM) without affecting PPARγ (IC50 = 31.65 mM) in vitro; enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes; dietary administration lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice at 100 mg/kg; prevents neurodegeneration in a C. elegans model of Parkinson’s disease; prevents overactivation of mTOR in the MPTP-induced and En+/- mouse models of Parkinson’s disease

Formal name: 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Synonyms: 

Molecular weight: 370.4

CAS: 146062-49-9

Purity: ≥98%

Formulation: A crystalline solid

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