A STING agonist; binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM

MSA-2 – 1 mg

Brand:
Cayman
CAS:
129425-81-6
Storage:
-20
UN-No:
Non-Hazardous - /

MSA-2 is an agonist of stimulator of interferon genes (STING).{49698} It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3′-cGAMP (Item No. 19887) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively.{57197} It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.  

 

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Description

A STING agonist; binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively); induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3’-cGAMP at 30 μM; reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression at 450 μg, intratumorally, and 50 mg/kg, s.c.; acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models

Formal name:

Synonyms:  5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid

Molecular weight: 294.3

CAS: 129425-81-6

Purity: ≥98%

Formulation: A crystalline solid

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