A selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM); reduces H3R2me2a in HEK293 cells (IC50 = 0.97 µM) and also

MS049 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
2095432-59-8
Storage:
-20
UN-No:
Non-Hazardous - /

MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).{32050} It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.{32050} MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.{32050} For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

 

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Description

A selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM); reduces H3R2me2a in HEK293 cells (IC50 = 0.97 µM) and also, unexpectedly, to reduce H4R3me2a in HEK293 cells

Formal name: N-methyl-4-(phenylmethoxy)-1-piperidineethanamine, dihydrochloride

Synonyms: 

Molecular weight: 321.3

CAS: 2095432-59-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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