A potent

MS023 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
2108631-19-0
Storage:
-20
UN-No:
Non-Hazardous - /

Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.{23166} MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).{30648} It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.{30648} See the Structural Genomics Consortium (SGC) website for more information.  

 

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Description

A potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively)

Formal name: N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine, trihydrochloride

Synonyms: 

Molecular weight: 396.8

CAS: 2108631-19-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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