Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides

MS-PPOH – 1 mg

Brand:
Cayman
CAS:
206052-02-0
Storage:
-20
UN-No:
Non-Hazardous - /

Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}  

 

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SKU: 75770 - 1 mg Category:

Description

Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}

Formal name: N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide

Synonyms: 

Molecular weight: 323.4

CAS: 206052-02-0

Purity: ≥98%

Formulation: A crystalline solid

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