An inhibitor of HDACs that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM); does not inhibit HDAC8; induces p21/CIP1/WAF1

MS-275 – 1 mg

Brand:
Cayman
CAS:
209783-80-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}  

 

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Description

An inhibitor of HDACs that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM); does not inhibit HDAC8; induces p21/CIP1/WAF1, slowing cell growth, differentiation, and tumor development in vivo

Formal name: N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester

Synonyms:  Entinostat|SNDX 275

Molecular weight: 376.4

CAS: 209783-80-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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