A cell-permeable inhibitor of JAK3

MS-1020 – 1 mg

Brand:
Cayman
CAS:
1255516-86-9
Storage:
-20
UN-No:
Non-Hazardous - /

MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM.{22389} It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death.{22389}  

 

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Description

A cell-permeable inhibitor of JAK3, strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM; without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2

Formal name: 1-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

Synonyms: 

Molecular weight: 346.4

CAS: 1255516-86-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|JAK Signaling

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