Description
A Mer and FLT3 inhibitor (IC50s = 1.3 and 1 nM, respectively); inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively); inhibits Mer phosphorylation in MOLM-14 and MV4-11 AML cells from 10-300 nM; reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM); increases survival in a NOMO-1 and MOLM-14 AML mouse xenograft models at 65 and 50 mg/kg, respectively
Formal name: trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol
Synonyms:
Molecular weight: 488.7
CAS: 1429882-07-4
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
