A competitive purinergic P2Y1 receptor antagonist (Kb = 102 nM); selective for P2Y1 over P2Y2

MRS2179 (ammonium salt) – 1 mg

Brand:
Cayman
CAS:
228264-19-5
Storage:
-20
UN-No:
Non-Hazardous - /

MRS2179 is a competitive purinergic P2Y1 receptor antagonist (Kb = 102 nM).{53657} It is selective for P2Y1 over P2Y2, P2Y4, P2Y6, P2Y12, and P2Y13, as well as P2X1-4, receptors at 10 µM.{19258,53658} MRS2179 reduces phospholipase C (PLC) activity induced by the P2Y receptor agonist 2-methylthioadenosine diphosphate (2-MeSADP; Item No. 21230) with an IC50 value of 331 nM in turkey erythrocyte membranes that endogenously express high levels of the P2Y1 receptor.{53657} It inhibits platelet shape change and aggregation induced by ADP (Item No. 21121) in washed isolated human platelets when used at a concentration of 10 µM.{33272} MRS2179 (50 mg/kg, i.v.) prolongs the length of tail bleeding time in mice, as well as decreases platelet thrombus formation in a mouse model of iron chloride-induced arterial thrombosis.{33272,53659}  

 

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SKU: 10011450 - 1 mg Category:

Description

A competitive purinergic P2Y1 receptor antagonist (Kb = 102 nM); selective for P2Y1 over P2Y2, P2Y4, P2Y6, P2Y12, and P2Y13, as well as P2X1-4, receptors at 10 µM; reduces 2-MeSADP-induced PLC activity (IC50 = 331 nM in turkey erythrocyte membranes); inhibits ADP-induced platelet shape change and aggregation in washed isolated human platelets at 10 µM; prolongs the length of tail bleeding time in mice, as well as decreases platelet thrombus formation in a mouse model of iron chloride-induced arterial thrombosis at 50 mg/kg

Formal name: 3′-adenylic acid, 2′-deoxy-N-methyl-5′-(dihydrogen phosphate), ammonium salt

Synonyms: 

Molecular weight: 425.2

CAS: 228264-19-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis

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