A tubulin polymerization inhibitor; inhibits proliferation of A549

MPT0B014 – 5 mg

Brand:
Cayman
CAS:
1215208-59-5
Storage:
-20
UN-No:
- 2811 / 6.1

MPT0B014 is an inhibitor of tubulin polymerization.{53719} It inhibits proliferation of A549, H1299, and H226 human non-small cell lung cancer (NSCLC) cells (IC50s = 0.041, 0.046, and 0.041 µM, respectively), as well as adriamycin-resistant NCI/ADR cells that overexpress P-glycoprotein (IC50 = ~0.03 µM). MPT0B014 (0.3 µM) induces cell cycle arrest at the G2/M phase and apoptosis in A549 cells. It reduces tumor growth in an A549 mouse xenograft model when administered in combination with the EGFR tyrosine kinase inhibitor erlotinib (Item No. 10483).  

 

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Description

A tubulin polymerization inhibitor; inhibits proliferation of A549, H1299, and H226 human NSCLC cells (IC50s = 0.041, 0.046, and 0.041 µM, respectively), as well as adriamycin-resistant NCI/ADR cells that overexpress P-glycoprotein (IC50 = ~0.03 µM); induces cell cycle arrest at the G2/M phase and apoptosis in A549 cells at 0.3 µM; reduces tumor growth in an A549 mouse xenograft model when administered in combination with erlotinib

Formal name: 6-quinolinyl(3,4,5-trimethoxyphenyl)methanone

Synonyms: 

Molecular weight: 323.3

CAS: 1215208-59-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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