An inhibitor of MPS1/TTK (IC50 = 5.8 nM); inhibits MPS1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1

MPS1/TTK Inhibitor – 10 mg

Brand:
Cayman
CAS:
1202055-39-7
Storage:
-20
UN-No:
Non-Hazardous - /

MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors.{37673,37672} It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM.{37673} MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegregated chromosomes, with an increased number of errors at 100 nM compared with 50 nM. It also inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively).  

 

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SKU: 25554 - 10 mg Category:

Description

An inhibitor of MPS1/TTK (IC50 = 5.8 nM); inhibits MPS1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively)

Formal name: N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Synonyms: 

Molecular weight: 580.7

CAS: 1202055-39-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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