An inhibitor of Mps1 (IC50 = 145 nM); 1

Mps1-IN-2 – 5 mg

Brand:
Cayman
CAS:
1228817-38-6
Storage:
-20
UN-No:
Non-Hazardous - /

Mps1-IN-2 is an ATP-competitive inhibitor of the checkpoint kinase Mps1 (IC50 = 145 nM).{31848} It is 1,000-fold selective for Mps1 over a panel of 352 kinases at 10 μM, but does inhibit Plk1 (Kd = 61 nM).  

 

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Description

An inhibitor of Mps1 (IC50 = 145 nM); 1,000-fold selective for Mps1 over a panel of 352 kinases at 10 mM, but does inhibit Plk1 (Kd = 61 nM)

Formal name: 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-6H-pyrimido[4,5-b][1,4]diazepin-6-one

Synonyms: 

Molecular weight: 480.6

CAS: 1228817-38-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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