A selective inhibitor of Mps1 kinase (IC50 = 367 nM); disrupts the recruitment of Mad2 to kinetochores and increases the frequency of multipolar mitosis in U2OS cells

Mps1-IN-1 – 500 µg

Brand:
Cayman
CAS:
1125593-20-5
Storage:
-20
UN-No:
Non-Hazardous - /

Mps1-IN-1 is a selective inhibitor of monopolar spindle 1 (Mps1) kinase (IC50 = 367 nM), a dual-specificity kinase involved in spindle assembly checkpoint and the maintenance of chromosomal stability.{31848} It exhibits greater than 1,000-fold selectivity against a panel of 352 kinases.{31848} Mps1-IN-1 has been shown to disrupt the recruitment of Mad2 to kinetochores and to increase the frequency of multipolar mitosis in U2OS cells.{31848}  

 

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Description

A selective inhibitor of Mps1 kinase (IC50 = 367 nM); disrupts the recruitment of Mad2 to kinetochores and increases the frequency of multipolar mitosis in U2OS cells

Formal name: 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol

Synonyms:  Monopolar Spindle 1 Kinase Inhibitor 1|Mps1 Kinase Inhibitor 1

Molecular weight: 535.7

CAS: 1125593-20-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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