An active metabolite of MPTP

MPP+ Iodide – 50 mg

Brand:
Cayman
CAS:
36913-39-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

MPP+ is an active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism.{31390,31391,31393,31392} MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress.{31394} The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.{31394}  

 

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Description

An active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism; inhibits complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress

Formal name: 1-methyl-4-phenyl-pyridinium, monoiodide

Synonyms:  N-Methyl-4-Phenylpyridinium Iodide

Molecular weight: 297.1

CAS: 36913-39-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Toxins||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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