An imidazoline I1 and α2A-AR agonist (Kis = 56 and 150 nM

Moxonidine – 250 mg

Brand:
Cayman
CAS:
75438-57-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Moxonidine is an imidazoline 1 (I1) receptor agonist (Ki = 56 nM in a radioligand binding assay).{47043} It is also an agonist of the α2A-adrenergic receptor (α2A-AR; Ki = 150 nM in a radioligand binding assay). It is selective for I1 and α2A-AR receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively). Moxonidine decreases mean arterial pressure in spontaneously hypertensive rats when administered at a dose of 0.2 nmol injected into the rostral ventrolateral medulla oblongata (RVLM).{47044} It also reduces blood pressure in cynomolgus monkeys when administered at a dose of 167 µg/kg.{47043}  

 

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SKU: 25639 - 250 mg Category:

Description

An imidazoline I1 and α2A-AR agonist (Kis = 56 and 150 nM, respectively, in radioligand binding assays); selective for α2A-AR and I1 receptors over α1-, α2B, and α2C-ARs (Kis = >30,000, 1,000, and 2,000 nM, respectively); decreases mean arterial pressure in spontaneously hypertensive rats at 0.2 nmol injected into the RVLM; reduces blood pressure in cynomolgus monkeys at 167 µg/kg

Formal name: 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine

Synonyms:  LY326869

Molecular weight: 241.7

CAS: 75438-57-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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