Description
A fluoroquinolone antibiotic; active against 390 clinical isolates of various bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively); an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays); prevents S. aureus- and P. aeruginosa-induced increases in BALF neutrophil infiltration and reduces S. aureus- and P. aeruginosa-induced increases in lung CXCL1 and IL-1β levels in mouse models of bacterial pneumonia at 100 mg/kg twice per day for two days; decreases the number of lung and spleen CFUs in a mouse model of systemic M. tuberculosis infection at 100 mg/kg
Formal name: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
Synonyms: BAY 12-8039
Molecular weight: 437.9
CAS: 186826-86-8
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis
