A polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting; induces phasic contractions and acetylcholine release (EC50 = 2.5 nM) in isolated rabbit duodenal segments (10 nM-1µM)

Motilin (porcine) – 1 mg

Brand:
Cayman
CAS:
9072-41-7
Storage:
-20
UN-No:
Non-Hazardous - /

Motilin is a polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting.{33844} In isolated rabbit duodenal segments, porcine motilin (10 nM-1 µM) induced phasic contractions and acetylcholine release from enteric neurons (EC50 = 2.5 nM).{33804} Formulations containing motilin are used to increase gastrointestinal motility in patients with diabetic gastroparesis, often in combination with erythromycin (Item No. 17191), an antibiotic and agonist at the motilin receptor.{33844}  

 

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Description

A polypeptide hormone that stimulates gastric motility through release in the small intestine and into the general circulation during fasting; induces phasic contractions and acetylcholine release (EC50 = 2.5 nM) in isolated rabbit duodenal segments (10 nM-1µM)

Formal name: motilin (swine)

Synonyms: 

Molecular weight: 2,699.10

CAS: 9072-41-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides|Peptide Hormones||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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