A 5-HT4 agonist (Ki = 69.9 nM); selective for 5-HT4 over 5-HT1

Mosapride (citrate) – 250 mg

Brand:
Cayman
CAS:
112885-42-4
Storage:
-20
UN-No:
Non-Hazardous - /

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM).{52440,30682} It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM).{52440,30682} It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively).{39019} Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs.{52440} It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.  

 

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SKU: 30048 - 250 mg Category:

Description

A 5-HT4 agonist (Ki = 69.9 nM); selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors at 1 mM but also acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM); induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively); increases antral and duodenal, but not ileal or colonic, motility in conscious dogs at 0.5 and 1 mg/kg; increases gastric emptying in rats from 0.03-30 mg/kg

Formal name: 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide, 2-hydroxy-1,2,3-monopropanetricarboxylate

Synonyms:  AS-4370

Molecular weight: 614

CAS: 112885-42-4

Purity: ≥98%

Formulation: A solid

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