A prenylated flavonoid with diverse biological activities; inhibits UGT1A6

Morusin – 10 mg

Brand:
Cayman
CAS:
62596-29-6
Storage:
-20
UN-No:
Non-Hazardous - /

Morusin is a prenylated flavonoid that has been found in M. alba and has diverse biological activities, including enzyme inhibitory, anti-inflammatory, and antiproliferative properties.{52095,52094,52093,59092} It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 μM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 μM, respectively).{52095} Morusin (4 μM) inhibits histamine and leukotriene C4 (LTC4) production induced by A23187 (Item No. 11016) and phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in mouse MC/9 mast cells.{52094} It also inhibits the growth of MCF-7, MDA‑MB‑231, and MDA‑MB‑453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 μM, respectively).{52093} Morusin (12.5 mg/kg per day) decreases colonic tissue damage, TGF-β1 levels, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis.{59092}  

 

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SKU: 28857 - 10 mg Category:

Description

A prenylated flavonoid with diverse biological activities; inhibits UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 μM, respectively); inhibits CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 μM, respectively); inhibits A23187- and PMA-induced histamine and LTC4 production in mouse MC/9 mast cells at 4 μM; inhibits the growth of MCF-7, MDA‑MB‑231, and MDA‑MB‑453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 μM, respectively); decreases colonic tissue damage, TGF-β1 levels, and MMP-2 and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis at 12.5 mg/kg per day

Formal name: 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-buten-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one

Synonyms:  Mulberrochromene|NSC 649220

Molecular weight: 420.5

CAS: 62596-29-6

Purity: ≥98%

Formulation: A solid

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