A synthetic analog of dolastatin 10 that inhibits tubulin polymerization and exhibits potent cytotoxicity; commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity

Monomethyl Auristatin E – 10 mg

Brand:
Cayman
CAS:
474645-27-7
Storage:
-20
UN-No:
Non-Hazardous - /

Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization.{28232} Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.{28971,28972} MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.{28972,28973}  

 

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Description

A synthetic analog of dolastatin 10 that inhibits tubulin polymerization and exhibits potent cytotoxicity; commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity

Formal name: N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

Synonyms:  Brentuximab vedotin|MMAE

Molecular weight: 718

CAS: 474645-27-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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