A selective inhibitor of ANO1 (IC50 = 0.08 µM in Xenopus oocytes)

MONNA – 10 mg

Brand:
Cayman
CAS:
1572936-83-4
Storage:
-20
UN-No:
Non-Hazardous - /

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 µM in Xenopus oocytes), a calcium-activated chloride channel (CaCC).{34636} It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 µM. MONNA (10 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.{34635} It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.  

 

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Description

A selective inhibitor of ANO1 (IC50 = 0.08 µM in Xenopus oocytes), a CaCC; selective over several other chloride channels up to 10 µM; induces full vasorelaxation of preconstructed mouse isolated mesenteric arteries when applied at 10 µM

Formal name: 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

Synonyms: 

Molecular weight: 338.3

CAS: 1572936-83-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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