A synthetic glucocorticoid; reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury at 3 mg/kg; intranasal administration reduces nose-rubbing behavior

Mometasone – 500 µg

Brand:
Cayman
CAS:
105102-22-5
Storage:
-20
UN-No:
Non-Hazardous - /

Mometasone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic activities.{60125,60126,60127} In vivo, mometasone (3 mg/kg) reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury.{60125} Intranasal administration of mometasone (0.2 µg/animal) reduces nose-rubbing behavior, sneezing, and nasal mucosal levels of IL-4 in a mouse model of allergic rhinitis.{60126} Mometasone also reduces nasal mucosal epithelial destruction, fibrosis, and cilia loss in a rat model of rhinitis medicamentosa induced by oxymetazoline (Item No. 23826).  

 

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Description

A synthetic glucocorticoid; reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury at 3 mg/kg; intranasal administration reduces nose-rubbing behavior, sneezing, and nasal mucosal levels of IL-4 in a mouse model of allergic rhinitis at 0.2 µg/animal; reduces nasal mucosal epithelial destruction, fibrosis, and cilia loss in a rat model of oxymetazoline-induced rhinitis medicamentosa

Formal name: (11β,16α)-9,21-dichloro-11,17-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  (+)-Mometasone

Molecular weight: 427.4

CAS: 105102-22-5

Purity: ≥90%

Formulation: A solid

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