A peripherally acting antitussive agent; inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg

Moguisteine – 250 mg

Brand:
Cayman
CAS:
119637-67-1
Storage:
-20
UN-No:
Non-Hazardous - /

Moguisteine is a peripherally acting antitussive agent.{49654,49655} It inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively).{49655} Moguisteine (75 and 150 mg/kg, p.o.) prevents bronchoalveolar lavage fluid (BALF) eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation.{49656} It inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs when administered at a dose of 30 mg/kg.  

 

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SKU: 30362 - 250 mg Category:

Description

A peripherally acting antitussive agent; inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s = 5.5 and >20 mg/kg, respectively); prevents BALF eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation; inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs at 30 mg/kg

Formal name: 2-[(2-methoxyphenoxy)methyl]-β-oxo-3-thiazolidinepropanoic acid, ethyl ester

Synonyms:  BBR 2173

Molecular weight: 339.4

CAS: 119637-67-1

Purity: ≥98%

Formulation: A crystalline solid

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