Blocks and reverses platelet aggregation induced by such triggers as collagen

MNS – 10 mg

Brand:
Cayman
CAS:
1485-00-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

MNS is a β-nitrostyrene that blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619 (Item No. 16450), and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively).{24470,24469} It reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM, respectively) in vitro.{24470,24471}  

 

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Description

Blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619, and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively); reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM, respectively) in vitro

Formal name: 5-(2-nitroethenyl)-1,3-benzodioxole

Synonyms:  3,4-Methylenedioxy-β-nitrostyrene|NSC 10120|NSC 105303|NSC 170724|Syk Inhibitor III

Molecular weight: 193.2

CAS: 1485-00-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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