A cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity; inhibits mouse macrophage metalloelastase MME/MMP-12 (IC50 = 13 nM)

MMP-3 Inhibitor VIII – 500 µg

Brand:
Cayman
CAS:
208663-26-7
Storage:
-20
UN-No:
Non-Hazardous - /

Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation.{28397} MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity.{28399} This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.{28398}  

 

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Description

A cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity; inhibits mouse macrophage metalloelastase MME/MMP-12 (IC50 = 13 nM)

Formal name: N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-4-methyl-pentanamide

Synonyms:  Matrix Metalloproteinase-3 Inhibitor VIII|Stromelysin-1 Inhibitor VIII

Molecular weight: 406.5

CAS: 208663-26-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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