An analog of SB-3CT that irreversibly inhibits MMP-2 (Ki = 2.4 µM); less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM

MMP-2 Inhibitor II – 10 mg

Brand:
Cayman
CAS:
869577-51-5
Storage:
-20
UN-No:
Non-Hazardous - /

MMP-2 Inhibitor II is an oxirane p-sulfonamido analog of SB-3CT (Item No. 16337) that irreversibly inhibits matrix metalloproteinase-2 (MMP-2; Ki = 2.4 µM).{30467} It less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively) and does not inhibit MMP-3, -7, or -9.{30467} MMP-2 Inhibitor II, at 5 µM, attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells.{30468} It has also been used to examine the role of MMP-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation.{30469}  

 

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Description

An analog of SB-3CT that irreversibly inhibits MMP-2 (Ki = 2.4 µM); less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively); attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells

Formal name: N-[4-[4-[(2-oxiranylmethyl)sulfonyl]phenoxy]phenyl]-methanesulfonamide

Synonyms:  ​Matrix Metalloproteinase-2 Inhibitor II

Molecular weight: 383.4

CAS: 869577-51-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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