A hydroxamate-based

MMP-2 Inhibitor I – 5 mg

Brand:
Cayman
CAS:
10335-69-0
Storage:
-20
UN-No:
Non-Hazardous - /

MMP-2 Inhibitor I is a hydroxamate-based, long-chain fatty acid that acts as a reversible inhibitor of matrix metalloproteinase (MMP)-2 (Ki = 1.6 µM), a protein implicated in the pathological breakdown of extracellular matrix proteins.{31343} Increased levels of MMP-2 are associated with tumor invasion and metastasis. This compound has been shown to attenuate cancer cell migration.{31344} It has also been used to preserve blood-brain barrier function in a rat model of pneumococcal meningitis.{31342}  

 

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Description

A hydroxamate-based, long-chain fatty acid that reversibly inhibits MMP-2 (Ki = 1.6 µM); attenuates cancer cell migration and has been shown to preserve blood-brain barrier function in a rat model of pneumococcal meningitis

Formal name: N-hydroxy-9Z-octadecenamide

Synonyms:  ​Matrix Metalloproteinase-2 Inhibitor I|cis-9-Octadecenoyl-N-hydroxylamide|Oleylhydroxamate

Molecular weight: 297.5

CAS: 10335-69-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Neuroscience

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