An orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models

MLN2480 – 5 mg

Brand:
Cayman
CAS:
1096708-71-2
Storage:
-20
UN-No:
Non-Hazardous - /

MLN2480 is an orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.{31570} It shows antitumor activity in melanoma, colon, lung, and pancreatic cancer xenograft models.{31568} MLN2480 demonstrates synergistic activity with TAK-733, an allosteric MEK kinase inhibitor.{31567}  

 

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SKU: 19675 - Category:

Description

An orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models

Formal name: 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide

Synonyms:  BIIB-024|TAK-580

Molecular weight: 506.3

CAS: 1096708-71-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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