A cell-permeable STAT3 activator (EC50 = 2 nM) that is more than 28

ML115 – 1 mg

Brand:
Cayman
CAS:
912798-42-6
Storage:
-20
UN-No:
Non-Hazardous - /

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.{7286,11981} ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB.{29820} It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6.{29820} As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.{29820}  

 

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Description

A cell-permeable STAT3 activator (EC50 = 2 nM) that is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB; increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6

Formal name: N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide

Synonyms:  CID 6619100|SID 14735210

Molecular weight: 322.7

CAS: 912798-42-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Immunology & Inflammation

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