A positive allosteric modulator of group III mGluRs (EC50s = 108

ML-396 – 25 mg

Brand:
Cayman
CAS:
1630936-95-6
Storage:
-20
UN-No:
Non-Hazardous - /

ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.{46721} ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.{46722}  

 

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SKU: 29167 - 25 mg Category:

Description

A positive allosteric modulator of group III mGluRs (EC50s = 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays); potentiates LSP4-2022-induced reductions in fEPSP slopes in mouse hippocampal slices; restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome at 30 mg/kg

Formal name: N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide

Synonyms:  VU0422288

Molecular weight: 360.2

CAS: 1630936-95-6

Purity: ≥98%

Formulation: A solid

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