A selective and reversible inhibitor of LYPLA2 (Kis = 230 and >10

ML-349 – 5 mg

Brand:
Cayman
CAS:
890819-86-0
Storage:
-20
UN-No:
Non-Hazardous - /

ML-349 is a selective and reversible inhibitor of lysophospholipase 2 (LYPLA2; Kis = 230 and >10,000 nM for human recombinant LYPLA2 and LYPLA1, respectively).{41062} Treatment with ML-349 results in >95% inhibition of LYPLA2 with no change in the activity of 25 other serine hydrolases in BW5147 murine T cell hybridoma cells. ML-349 almost completely inhibits LYPLA2 in HEK293T and mouse T cells and in vivo in murine lung, heart, and kidneys. It partially inhibits LYPLA2 in murine brain.  

 

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Description

A selective and reversible inhibitor of LYPLA2 (Kis = 230 and >10,000 nM for human recombinant LYPLA2 and LYPLA1, respectively); inhibits LYPLA2 (>95%) with no change in the activity of 25 other serine hydrolases in BW5147 murine T cell hybridoma cells; almost completely inhibits LYPLA2 in HEK293T and mouse T cells and in vivo in murine lung, heart, and kidneys; partially inhibits LYPLA2 in murine brain

Formal name: (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-methanone

Synonyms: 

Molecular weight: 454.6

CAS: 890819-86-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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