An activator of the heat shock response; induces the expression of HSP70

ML-346 – 10 mg

Brand:
Cayman
CAS:
100872-83-1
Storage:
-20
UN-No:
Non-Hazardous - /

ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27.{38557} It induces the expression of the oxidative stress response genes HO1, GCLM, and BiP in mouse embryonic fibroblasts (MEFs) and pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis. It promotes folding of metastable proteins in models of conformational disease, including cellular models of Huntingtin aggregation and cystic fibrosis. It reduces aggregate formation in PC12 cells expressing human Huntingtin exon 1 containing a 74 glutamine expansion when used at a concentration of 10 µM. It also corrects trafficking of cystic fibrosis transmembrane conductance regulator proteins bearing the F508 deletion (ΔF508-CFTR) mutation carried by the majority of cystic fibrosis patients, leading to increased cell surface expression.  

 

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SKU: 23844 - 10 mg Category:

Description

An activator of the heat shock response; induces the expression of HSP70, HSP40, and HSP27; pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis; promotes folding of metastable proteins in models of conformational disease; reduces aggregate formation in PC12 cells expressing an expanded Huntingtin gene when used at a concentration of 10 µM; corrects trafficking of ΔF508-CFTR-containing proteins, leading to increased cell surface expression

Formal name: 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione

Synonyms: 

Molecular weight: 272.3

CAS: 100872-83-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Cystic Fibrosis||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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