Description
An activator of the heat shock response; induces the expression of HSP70, HSP40, and HSP27; pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis; promotes folding of metastable proteins in models of conformational disease; reduces aggregate formation in PC12 cells expressing an expanded Huntingtin gene when used at a concentration of 10 µM; corrects trafficking of ΔF508-CFTR-containing proteins, leading to increased cell surface expression
Formal name: 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione
Synonyms:
Molecular weight: 272.3
CAS: 100872-83-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Cystic Fibrosis||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
